Hearing and the brain

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The story so far

If you’ve been following audiology news recently, chances are you’ve heard about ACHIEVE: the landmark study to determine whether treating hearing loss in older adults could reduce cognitive decline – a potential precursor to dementia. The study’s positive results (see below) have understandably generated a lot of media buzz. But for many audiology experts, the findings support what they’ve suspected for years. That hearing health is vital to overall health, which is why addressing hearing loss can play a key role in promoting cognitive wellbeing. In fact, events over the past decade have increasingly added weight to the hearing and dementia connection. With new research taking this story from enticing to now potentially enormous. Let’s look back at some of the major milestones so far… A connection is made In a watershed 2011 study, Johns Hopkins professor Dr Frank R. Lin and colleagues find that seniors with hearing loss are significantly more likely to develop dementia over time than those who retain their hearing. In fact, those with mild, moderate, or severe hearing loss had a respective twofold, threefold, and fivefold risk of developing dementia. Put simply, the higher the hearing loss, the higher the likelihood of developing this chronic condition. Opening up for more Continuing his run of research, another Lin-led study finds that hearing impairment in older adults is independently associated with accelerated cognitive decline and incident dementia. The study wasn’t yet able to explore if hearing aid use could moderate this association, paving the way for more investigation around hearing loss interventions. Stronger evidence needed Despite the growing link between hearing loss and cognitive decline, there’s caution around whether hearing interventions can delay the onset of dementia. As demonstrated by new World Health Organization (WHO) guidelines stating that there’s insufficient evidence to recommend the use of hearing aids to reduce the risk of cognitive decline. Potentially modifiable risk factors In a Lancet Commission report on dementia prevention, intervention, and care, hearing loss is listed as the biggest potentially modifiable risk factor out of 12. These are factors that might prevent or delay up to 40% of dementias. And as protection against dementia, this meta-analysis report states that hearing aids appear to reduce the excess risk associated with hearing loss. The hearing aid effect A new study in the peer-reviewed Alzheimer's & Dementia journal sets out to examine for the first time the effect of hearing aid usage in the conversion from mild cognitive impairment to dementia. The study finds that hearing aid users with a hearing impairment are at a significantly lower risk of developing all-cause dementia – a conclusion that demands further testing. A real turning point The arrival of the eagerly-anticipated ACHIEVE study – once again led by Dr Frank R. Lin – marks a new chapter in this ever-evolving story. Among its many results, the study finds that for people at higher risk of cognitive decline, hearing intervention could slow its progression by 48%. Suggesting that maintaining good hearing may lower the risk of developing dementia. As the past decade has shown, a lot’s happened to establish hearing loss as one of the potentially biggest risk factors for developing dementia. And now there’s potential proof that intervening with hearing aids may actually reduce this risk. Clearly, more investigation is needed to see how hearing aids provide the cognitive benefits and to better understand the longer-term benefits of hearing intervention. But one thing’s for sure – this is a fast-moving story where audiology experts will do well to get ahead of the curve. Watch this space… [[CTA section]] Want to know more about what the landmark ACHIEVE study tells us? We review the story here

If you’ve been following audiology news recently, chances are you’ve heard about ACHIEVE: the landmark study to determine whether treating hearing loss in older adults could reduce cognitive decline1 – a potential precursor to dementia. 


The study’s positive results (see below) have understandably generated a lot of media buzz. But for many audiology experts, the findings support what they’ve suspected for years. That hearing health is vital to overall health, which is why addressing hearing loss can play a key role in promoting cognitive wellbeing. 


In fact, events over the past decade have increasingly added weight to the hearing and dementia connection. With new research taking this story from enticing to now potentially enormous. Let’s look back at some of the major milestones so far… 

2011
A connection is made

In a watershed 2011 study2, Johns Hopkins professor Dr Frank R. Lin and colleagues find that seniors with hearing loss are significantly more likely to develop dementia over time than those who retain their hearing. In fact, those with mild, moderate, or severe hearing loss had a respective twofold, threefold, and fivefold risk of developing dementia. Put simply, the higher the hearing loss, the higher the likelihood of developing this chronic condition.

2014
Opening up for more

Continuing his run of research, another Lin-led study3 finds that hearing impairment in older adults is independently associated with accelerated cognitive decline and incident dementia. The study wasn’t yet able to explore if hearing aid use could moderate this association, paving the way for more investigation around hearing loss interventions. 

2019
Stronger evidence needed

Despite the growing link between hearing loss and cognitive decline, there’s caution around whether hearing interventions can delay the onset of dementia. As demonstrated by new World Health Organization (WHO) guidelines4 stating that there’s insufficient evidence to recommend the use of hearing aids to reduce the risk of cognitive decline.  

2020
Potentially modifiable risk factors

In a Lancet Commission report on dementia prevention, intervention, and care5, hearing loss is listed as the biggest potentially modifiable risk factor out of 12. These are factors that might prevent or delay up to 40% of dementias. And as protection against dementia, this meta-analysis report states that hearing aids appear to reduce the excess risk associated with hearing loss. 

2021
The hearing aid effect

A new study in the peer-reviewed Alzheimer's & Dementia journal6 sets out to examine for the first time the effect of hearing aid usage in the conversion from mild cognitive impairment to dementia. The study finds that hearing aid users with a hearing impairment are at a significantly lower risk of developing all-cause dementia – a conclusion that demands further testing. 

2023
A real turning point

The arrival of the eagerly-anticipated ACHIEVE study7 – once again led by Dr Frank R. Lin – marks a new chapter in this ever-evolving story. Among its many results, the study finds that for people at higher risk of cognitive decline, hearing intervention could slow its progression by 48%. Suggesting that maintaining good hearing may lower the risk of developing dementia.

Get ahead of the curve

As the past decade has shown, a lot’s happened to establish hearing loss as one of the potentially biggest risk factors for developing dementia. And now there’s potential proof that intervening with hearing aids may actually reduce this risk. 

Clearly, more investigation is needed to see how hearing aids provide the cognitive benefits and to better understand the longer-term benefits of hearing intervention. But one thing’s for sure – this is a fast-moving story where audiology experts will do well to get ahead of the curve. 

Watch this space…  

Want to know more about what the landmark ACHIEVE study tells us?

We review the story here

references

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  1.  Lin FR, Pike JR, Albert MS, et al. Hearing intervention versus health education control to reduce cognitive decline in older adults with hearing loss in the USA (ACHIEVE): a multicentre, randomised controlled trial. Lancet 2023; published online July 18. https://doi.org/10.1016/S0140-6736(23)01406-X
  2.  Lin FR, Metter EJ, O’Brien J, et al. Hearing Loss and Incident Dementia. Archives of Neurology, Feb 2011, 68(2): 214–220. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277836/ 
  3.  Lin FR, Ferrucci L, et al. Association of Hearing Impairment with Brain Volume Changes in Older Adults. NeuroImage, April 2014, vol.90. https://doi.org/10.1016/j.neuroimage.2013.12.059 
  4.  WHO (2017). Global action plan on the public health response to dementia 2017–2025. World Health Organization. https://apps.who.int/iris/handle/10665/259615 
  5.  Livingston, G. et al. (2020) Dementia prevention, intervention, and care: 2020 report of the Lancet Commission, The Lancet, vol. 396, issue: 10248, https://www.thelancet.com/article/S0140-6736(20)30367-6/fulltext 
  6.  Bucholc M, McClean PL, et al. Association of the use of hearing aids with the conversion from mild cognitive impairment to dementia and progression of dementia: A longitudinal retrospective study. Alzheimer’s & Dementia (TRCI). Feb 2021, vol.7(1):e12122. https://doi.org/10.1002/trc2.12122 
  7.  Lin FR, Pike JR, Albert MS, et al. Hearing intervention versus health education control to reduce cognitive decline in older adults with hearing loss in the USA (ACHIEVE): a multicentre, randomised controlled trial. Lancet 2023; published online July 18. https://doi.org/10.1016/S0140-6736(23)01406-X
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